In June of this year the U.S. Food & Drug Administration (FDA) issued a warning[1] about the popular diabetes drug Actos® (pioglitazone). The FDA had found that the use of pioglitazone for more than a year may be linked to an increased risk of bladder cancer.
The FDA warning was based on a study that shows that an increased risk of bladder cancer was found among patients with the longest exposure to pioglitazone, and in those exposed to the highest cumulative dose of pioglitazone. The warning notes that France and Germany both moved to restrict the use of pioglitazone after a French study linked an increased risk of bladder cancer to long-term use.
Pioglitazone is also a key ingredient in the drugs Actoplus Met, Actoplus Met XR and Duetact. In the first ten months of 2010, more than 2.3 million patients were prescribed a pioglitazone-containing product.
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